Liverpool Coastguard covers waters from the Point of Ayr on the Dee Estuary through Merseyside, Morecambe and South Cumbria, all the way up to the Mull of Galloway.
It is thought 20 jobs will be lost at the centre in Crosby as a result of the emergency call centre closure.
Emergencies will be handled by the Holyhead station in North Wales, which has been chosen to take the calls.
It is widely discussed that the closures and lack of local knowledge of the local area from North Wales could impact the effectiveness of carrying out operations.
Liverpool Riverside MP Louise Ellman, who chairs the transport committee, said: “I am concerned that lives could be be put in danger.
“I do think it’s a matter of concern that local knowledge is being disregarded in this way.
“I think computerised information is important but it can’t replace essential local knowledge.”
The closing comes as online campaign is trying fight against the closure.
Liverpool Coastguard station helped co-ordinate the response to the Morecambe Bay tragedy in February 2004 which claimed the life of 21 cockle pickers.
From 2000 – 2013 Liverpool coastguard was called out to 10,929 incidents.